Modulation
of one of the most important blood cells involved in the human immune
response may effectively treat and prevent the symptoms of type 2
diabetes and periodontitis simultaneously, scientists say.
Researchers have found that B cells, blood cells involved in the
human immune response, promote inflammation and bone loss in type 2
diabetes-associated periodontal disease. These findings support the
idea that treatments that manipulate the responses of B cells may
treat or prevent this complication. "Our study identified common
inflammatory mechanisms shared by type 2 diabetes and periodontal
disease. It paves the way for the development of novel therapeutics
which aim to simultaneously treat both type 2 diabetes and its
complications," said Min Zhu, a researcher involved in the work
from the department of microbiology at Boston University School of
Medicine in Boston, Massachusetts. To make this discovery, scientists
used an experimental model (mouse model) of periodontal disease and
applied it to two groups. The first group had a genetic alteration
that knocked out all B cells. The second group had normal B cell
levels. When fed a low-fat diet, without development of obesity and
type 2 diabetes, both groups demonstrated a similar extent of oral
bone loss and inflammation. However, when they were fed a high-fat
diet, became obese and developed type 2 diabetes, oral bone loss and
inflammation occurred in the normal group with B cells, but did not
develop in the group with the altered gene to knock out the B cells.
This suggests that the B cell-response might be a viable target for
pharmacological intervention in both type 2 diabetes and periodontal
disease, as well as potentially in other type 2 diabetes
complications. The research was published in the Journal of Leukocyte
Biology.
Correlating the ups and down in the Indian rupee with the stock market, Vijay Bhambwani, CEO, bsplindia.com, suggests that if the rupee continues with its downward fall, the Indian stock market may fall breach October lows and fall further. “If the rupee falls below the 53.0-53.50 mark vis-a-vis the USD, expect a mini meltdown atleast in the equity markets. In that case, the 2250 level (on Nifty) will be breached easily to form a new low. The possibility of that low being below the 2000 levels on the Nifty spot is fairly high,” he says. Bhambwani supports his outlook by comparing the value of rupee at the time of October lows. “The October 2008 lows were made with the INR at 51.20 - 51.40 band. The rupee has breached the 52 level since then. Clearly the nation’s ‘share price’ (currency) indicates weakness. The curency market is a far more accurate barometer of the nation’s health compared to the equity indices. Whether you like it or not, we are under siege. Had it not been March (NAV ...
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