Modulation
of one of the most important blood cells involved in the human immune
response may effectively treat and prevent the symptoms of type 2
diabetes and periodontitis simultaneously, scientists say.
Researchers have found that B cells, blood cells involved in the
human immune response, promote inflammation and bone loss in type 2
diabetes-associated periodontal disease. These findings support the
idea that treatments that manipulate the responses of B cells may
treat or prevent this complication. "Our study identified common
inflammatory mechanisms shared by type 2 diabetes and periodontal
disease. It paves the way for the development of novel therapeutics
which aim to simultaneously treat both type 2 diabetes and its
complications," said Min Zhu, a researcher involved in the work
from the department of microbiology at Boston University School of
Medicine in Boston, Massachusetts. To make this discovery, scientists
used an experimental model (mouse model) of periodontal disease and
applied it to two groups. The first group had a genetic alteration
that knocked out all B cells. The second group had normal B cell
levels. When fed a low-fat diet, without development of obesity and
type 2 diabetes, both groups demonstrated a similar extent of oral
bone loss and inflammation. However, when they were fed a high-fat
diet, became obese and developed type 2 diabetes, oral bone loss and
inflammation occurred in the normal group with B cells, but did not
develop in the group with the altered gene to knock out the B cells.
This suggests that the B cell-response might be a viable target for
pharmacological intervention in both type 2 diabetes and periodontal
disease, as well as potentially in other type 2 diabetes
complications. The research was published in the Journal of Leukocyte
Biology.
Legendary playback singer Manna Dey, who mesmerised generations of listeners with his inimitable voice for over five decades with hits like 'ay mere pyara watan', 'laaga chunri me daag' and 'poocho na kaise', died at a hospital here today at the age of 94 after prolonged illness. Dey, who was in and out of Narayana Hrudayalaya Hospital in the last five months for respiratory and renal problems, died of cardiac arrest with his daughter Shumita Deb and son-in-law Jnanranjan Deb by his bedside when the end came at 3.50 AM. The condition of Dey, who had made Bangalore his home for the last many years, deteriorated since yesterday afternoon, hospital spokesman Vasuki said. With the demise of Dey, the void has become complete in the famous quartet of singers Rafi, Mukesh, and Kishore Kumar, who dominated the Hindi music industry from 1950s to 1970s. The mortal remains of Dey, whose unique voice lent a rare dimension to his persona, were cremate...
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