Modulation
of one of the most important blood cells involved in the human immune
response may effectively treat and prevent the symptoms of type 2
diabetes and periodontitis simultaneously, scientists say.
Researchers have found that B cells, blood cells involved in the
human immune response, promote inflammation and bone loss in type 2
diabetes-associated periodontal disease. These findings support the
idea that treatments that manipulate the responses of B cells may
treat or prevent this complication. "Our study identified common
inflammatory mechanisms shared by type 2 diabetes and periodontal
disease. It paves the way for the development of novel therapeutics
which aim to simultaneously treat both type 2 diabetes and its
complications," said Min Zhu, a researcher involved in the work
from the department of microbiology at Boston University School of
Medicine in Boston, Massachusetts. To make this discovery, scientists
used an experimental model (mouse model) of periodontal disease and
applied it to two groups. The first group had a genetic alteration
that knocked out all B cells. The second group had normal B cell
levels. When fed a low-fat diet, without development of obesity and
type 2 diabetes, both groups demonstrated a similar extent of oral
bone loss and inflammation. However, when they were fed a high-fat
diet, became obese and developed type 2 diabetes, oral bone loss and
inflammation occurred in the normal group with B cells, but did not
develop in the group with the altered gene to knock out the B cells.
This suggests that the B cell-response might be a viable target for
pharmacological intervention in both type 2 diabetes and periodontal
disease, as well as potentially in other type 2 diabetes
complications. The research was published in the Journal of Leukocyte
Biology.
Congress leader Manishankar Aiyar attracted opposition BJP's ire today in Rajya Sabha when he said he was not interested in listening to speech of a BJP member on vote on account, prompting the Chair to adjourn the House amid uproar. During the Zero Hour, Deputy Chairman P J Kurien allowed Aiyar, who wanted to ask a question, to do so, which was opposed by BJP members. Kurien asked Aiyar whether he yielded to allow others to speak, to which he said he had no objection and he can ask his question later. As the House got ready to initiate discussion on Vote on Account, Kurien said, "Let us reduce the discussion to two hours from four hours," which was opposed by BJP members including Piyush Goyal who was given a chance to speak on Vote on Account. When it was agreed that discussion will take place as per schedule, Aiyar remarked he was not interested in listening to the speech by BJP member. "You had given me the chance to ask a question
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